Boehringer Ingelheim Bio-Mycin® 200

Boehringer Ingelheim

Product Description

Bio-Mycin® 200 (oxytetracycline injection) is approved for use in beef and dairy cattle and is indicated in the treatment of:

  • Pneumonia and shipping fever complex associated with Pasteurella and Haemophilus.
  • Infectious bovine kerato-conjunctivitis (pinkeye) caused by Moraxella bovis.
  • Foot-rot and diphtheria caused by Fusobacterium necrophorum.
  • Bacterial enteritis (scours) caused by Escherichia coli.
  • Leptospirosis caused by Leptospira pomona.
  • Wound infections and acute metritis caused by strains of Staphylococci and Streptococci organisms sensitive to oxytetracycline.

In swine, BIO-MYCIN 200 is indicated in the treatment of bacterial enteritis caused by Escherichia coli, pneumonia caused by Pasteurella multocida and leptospirosis caused by Leptospira pomona.
In sows, BIO-MYCIN 200 is indicated for aid in control of infectious enteritis in suckling pigs caused by Escherichia coli.

Features & Benefits


  • BIO-MYCIN 200 is the only injectable product formulated with Select Carrier™.
  • SELECT CARRIER is a patented vehicle that reduces tissue irritation and cattle discomfort. Because of this unique carrier, costly injection-site lesions and post-treatment tissue reactions are minimized.
  • In a head-to-head study, BIO-MYCIN 200 showed reduced tissue damage in cattle after injection when compared to Nuflor® (florfenicol), Micotil® (tilmicosin injection), Liquamycin® LA-200® (oxytetracycline injectable solution) or Noromycin® 300 LA (oxytetracycline).1


  • BIO-MYCIN 200 treats a wide range of diseases including pinkeye, bovine respiratory disease, foot rot and leptospirosis.
  • BIO-MYCIN 200 is effective on various types of cattle: all beef cattle, lactating and non-lactating dairy cattle.


  • BIO-MYCIN 200 is more effective than LIQUAMYCIN LA-200, providing the immediate impact and long-lasting treatment animals need to recover. 2
  • Compared to cattle treated with LIQUAMYCIN LA-200, cattle treated with BIO-MYCIN 200 had higher peaks and longer duration of antibiotic levels in tissue. 2


  • BIO-MYCIN 200 has a low-dose volume with a pharmacokinetic profile similar to a 300 mg product.
  • Losses due to lesion trimming can cost up to $40 per head.3 So choosing the smoother BIO-MYCIN 200 can improve cattle profitability and performance.

Dosage Information

  • Consult your veterinarian prior to administering BIO-MYCIN 200.
  • Read and follow all label directions.
  • For Cattle: BIO-MYCIN 200 is to be administered by intramuscular, subcutaneous, or intravenous injection to beef cattle and dairy cattle. A single dosage of 9 milligrams of Bio-Mycin 200 per pound of body weight administered intramuscularly or subcutaneously is recommended in the treatment of shipping fever and pinkeye in conditions where re-treatment is impractical or inadvisable. BIO-MYCIN 200 can also be administered by intravenous, subcutaneous, or intramuscular injection at a level of 3 to 5 milligrams of oxytetracycline per pound of body weight per day. (see label for complete instructions)
  • See label for swine dosage instructions.

Safety Information

  • Discontinue use at least 28 days in cattle and 28 days in swine before slaughter to permit elimination of the drug from edible tissues. Milk taken from animals during treatment and for 96 hours after the last treatment must not be used for food. 
  • Rapid intravenous administration may result in animal collapse. Oxytetracycline should be administered intravenously slowly over a period of at least 5 minutes.
  • Do not use for more than 4 days. Do not inject more than 10 mL per site intramuscularly in mature cattle or 5 mL per site intramuscularly in swine. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal. Not for human use.

1 Dowling PM. Evaluation of subcutaneous and intramuscular injection sites of antimicrobials in calves. Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon. 1998;1-40.
2 Lechtenberg K and Apley M. Pharmacokinetics for Bio-Mycin® 200 (oxytetracycline injection) vs.Liquamycin® LA-200® (oxytetracycline injection) Serum Profiles following Sub-Q Administration. Technical Bulletin, Oakland, Neb.: Boehringer Ingelheim Animal Health USA Inc., 2019:1–2.
3 Hilton WM. Beef quality assurance injection sites and techniques. Purdue University Cooperative Extension Service. Available at: Accessed May 23, 2018

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